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http://us.battle.net/hearthstone/en/forum/topic/10259565877
In the closed beta test, you are only able to play with other players in the region that corresponds to your home region on your Battle.net account. As an example, if my home region is Canada, then I am a part of the North American closed beta test, and I am only able to play with others in the North American region.
In the future, we plan to allow players to play in regions that are outside of their home region.
When this happens, you will be able to pick which region you would like to play in. However, the important thing to remember is whenever you decide to change regions, your collection does not transfer over to the new region you would like to play on.
On the new region, you will have to start your progress over as if you were a new player to Hearthstone and nothing will carry over in-game.
We currently have no plans to allow players to play against other players across regions.
Zeriyah
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SexuaLobster's Grease Portal
D3 works the same way
I have to create new D3 characters as a USA region switching to Euro Region (if i play w my euro friends)
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